Aromatase Deficiency Confers Paradoxical Postischemic Cardioprotection
نویسندگان
چکیده
منابع مشابه
HIF-1α and paradoxical phenomena in cardioprotection.
Ischaemic preconditioning, i.e. one or several brief cycles of myocardial ischaemia/reperfusion preceding a more sustained period of myocardial ischaemia with subsequent reperfusion, does not increase the resulting size of myocardial infarction but paradoxically decreases it. Over the past 25 years, ischaemic preconditioning has become the key paradigm of endogenous cardioprotection, and numero...
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BACKGROUND Preconditioning with remifentanil (RPC) provides immediate cardioprotection in rats via all three types of opioid (OP) receptor. This study sought to investigate whether remifentanil also confers delayed cardioprotection via OP receptors. METHODS Male rats received preconditioning either by ischaemia (IPC; 5 min occlusion, 5 min reperfusion x 3) or with remifentanil (RPC; 1, 5, 10,...
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The volatile anesthetic, isoflurane, protects the heart from ischemia/reperfusion (I/R) injury. Aldehyde dehydrogenase 2 (ALDH2) is thought to be an endogenous mechanism against ischemia-reperfusion injury possibly through detoxification of toxic aldehydes. We investigated whether cardioprotection by isoflurane depends on activation of ALDH2.Anesthetized rats underwent 40 min of coronary artery...
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Recent data of ours demonstrate that naringenin, a flavanone derivative typical of the Citrus genus, possesses cardioprotective effects in rat hearts submitted to ischemia/reperfusion injury [Testai et al., 2013a]. These effects are due, at least in part, to a mitochondria-targeted action, since naringenin activates a mitochondrial calcium-dependent potassium channel (mitoBKCa), localized in th...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2011
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2011-1212